Oxymorphone Hydrochloride and Temazepam must not be used together. This combination is classified as CONTRAINDICATED.
The concurrent use of oxymorphone and temazepam significantly increases the risk of severe adverse effects, including profound sedation, respiratory depression, coma, and death. Patients may experience decreased level of consciousness, hypoventilation, bradycardia, and hypotension, which can progress rapidly.
Mechanism: Oxymorphone, an opioid agonist, and temazepam, a benzodiazepine, both exert central nervous system (CNS) depressant effects by acting on distinct receptors. Oxymorphone primarily acts on mu-opioid receptors, while temazepam enhances the activity of gamma-aminobutyric acid (GABA) at GABA-A receptors. The co-administration leads to an additive and synergistic depression of the CNS, including respiratory drive and consciousness.
Oxymorphone Hydrochloride vs. Temazepam
Compare Oxymorphone Hydrochloride and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Oxymorphone Hydrochloride
Oxymorphone Hydrochloride
Opioid Analgesics
RxDrug B
Temazepam
temazepam
Benzodiazepines
RxQuick Comparison
| Category | Oxymorphone Hydrochloride | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$800/month | $20–$70/month |
Oxymorphone Hydrochloride Overview
OXYMORPHONE HYDROCHLORIDE (brand name: Oxymorphone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxymorphone hydrochloride tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which…
Full Oxymorphone Hydrochloride guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →How Each Drug Works
Oxymorphone Hydrochloride
Oxymorphone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxymorphone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxymorphone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism …
Approved Uses (Indications)
Oxymorphone Hydrochloride
Oxymorphone hydrochloride tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration, and persist over the course of therapy [see Warnings and Precautions ] , reserve opioid analgesics, including oxymorphone hydrochloride for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate…
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Oxymorphone Hydrochloride
Temazepam
Cost Comparison
Oxymorphone Hydrochloride
$200–$800/month
Since a generic is not available, patients may find discounts using manufacturer coupons or patient assistance programs. Comparing prices at different pharmacies with discount cards can also help reduce costs.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
Compare prices for Oxymorphone Hydrochloride and Temazepam
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.