Combining Paroxetine and Propranolol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Paroxetine, a potent CYP2D6 inhibitor, can significantly increase plasma concentrations of propranolol, a beta-blocker primarily metabolized by CYP2D6. This elevated propranolol level can lead to enhanced beta-blockade effects, potentially causing severe bradycardia, hypotension, and heart block.
Mechanism: Paroxetine potently inhibits the cytochrome P450 2D6 (CYP2D6) enzyme. Propranolol is a substrate of CYP2D6, so its metabolism is reduced, leading to decreased clearance and increased systemic exposure.
Paroxetine vs. Propranolol Hydrochloride
Compare Paroxetine and Propranolol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Paroxetine
Paroxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Propranolol Hydrochloride
propranolol hydrochloride
Beta-Blockers
RxQuick Comparison
| Category | Paroxetine | Propranolol Hydrochloride |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $15–$70/month | $30-$100/month |
Paroxetine Overview
Paroxetine is a prescription medication used to help women manage moderate to severe hot flashes and night sweats (vasomotor symptoms) associated with menopause. While it belongs to a class of drugs that can affect brain chemicals, this specific formulation works differently and is not used to treat mental health conditions.
Full Paroxetine guide →Propranolol Hydrochloride Overview
Propranolol hydrochloride is a medication that helps manage conditions like high blood pressure, chest pain (angina), and prevents migraine headaches. It works by affecting certain signals in the body, which helps to slow the heart rate and relax blood vessels, making it easier for the heart to pump blood.
Full Propranolol Hydrochloride guide →How Each Drug Works
Paroxetine
Nonclinical studies have shown that paroxetine is an SSRI. Paroxetine capsules are not an estrogen, and its mechanism of action for the treatment of VMS is unknown.
Propranolol Hydrochloride
Mechanism of Action The mechanism of the antihypertensive effect of propranolol has not been established. Among the factors that may be involved in contributing to the antihypertensive action include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of p…
Approved Uses (Indications)
Paroxetine
Paroxetine Capsules are indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause. Limitation of Use: Paroxetine capsules are not indicated for the treatment of any psychiatric condition. Paroxetine capsules contain a lower dose of paroxetine than that used to treat depression, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder. The safety and efficacy of this lower dose of paroxetine in paroxetine capsules have not been established for any ps…
Propranolol Hydrochloride
INDICATIONS AND USAGE Hypertension Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated in the management of hypertension. They may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol Hydrochloride Extended-Release Capsules, USP, are not indicated in the management of hypertensive emergencies. Angina Pectoris Due to Coronary Atherosclerosis Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Migr…
Side Effects
Paroxetine
Propranolol Hydrochloride
Cost Comparison
Paroxetine
$15–$70/month
Paroxetine is available as a generic, which is significantly more affordable than the brand-name versions. Always compare prices using discount cards like GoodRx to find the lowest cost at different pharmacies.
Propranolol Hydrochloride
$30-$100/month
Despite the drug being listed as 'brand' in the prompt, Propranolol Hydrochloride is widely available as a generic. Look for generic versions to significantly reduce costs, and consider using discount cards like GoodRx.
Compare prices for Paroxetine and Propranolol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.