Combining Paroxetine and Timolol Maleate is a major interaction and should generally be avoided without close medical supervision.
Paroxetine, a potent CYP2D6 inhibitor, can significantly increase systemic exposure to timolol, a beta-blocker primarily metabolized by CYP2D6. This interaction can lead to enhanced beta-blockade, manifesting as severe bradycardia, hypotension, and potentially heart block.
Mechanism: Paroxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme, which is a primary metabolic pathway for timolol. This pharmacokinetic inhibition reduces timolol's clearance, leading to elevated plasma concentrations and prolonged pharmacological effects.
Paroxetine vs. Timolol Maleate
Compare Paroxetine and Timolol Maleate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Paroxetine
Paroxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Timolol Maleate
Timolol Maleate
Beta-Blockers
RxQuick Comparison
| Category | Paroxetine | Timolol Maleate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $15–$70/month | $50–$150/month |
Paroxetine Overview
Paroxetine is a prescription medication used to help women manage moderate to severe hot flashes and night sweats (vasomotor symptoms) associated with menopause. While it belongs to a class of drugs that can affect brain chemicals, this specific formulation works differently and is not used to treat mental health conditions.
Full Paroxetine guide →Timolol Maleate Overview
Timolol Maleate is an eye drop medication used to treat high pressure inside the eye. It works by helping to reduce the amount of fluid your eye produces, which in turn lowers the pressure. This medication is primarily prescribed for conditions like ocular hypertension and open-angle glaucoma to help protect your vision.
Full Timolol Maleate guide →How Each Drug Works
Paroxetine
Nonclinical studies have shown that paroxetine is an SSRI. Paroxetine capsules are not an estrogen, and its mechanism of action for the treatment of VMS is unknown.
Timolol Maleate
Mechanism of Action Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Timolol Maleate Ophthalmic Gel Forming Solution, when applied topically on the eye, has the action of reducing elevated, as well as normal intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk fa…
Approved Uses (Indications)
Paroxetine
Paroxetine Capsules are indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause. Limitation of Use: Paroxetine capsules are not indicated for the treatment of any psychiatric condition. Paroxetine capsules contain a lower dose of paroxetine than that used to treat depression, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder. The safety and efficacy of this lower dose of paroxetine in paroxetine capsules have not been established for any ps…
Timolol Maleate
INDICATIONS AND USAGE Timolol Maleate Ophthalmic Gel Forming Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Side Effects
Paroxetine
Timolol Maleate
Cost Comparison
Paroxetine
$15–$70/month
Paroxetine is available as a generic, which is significantly more affordable than the brand-name versions. Always compare prices using discount cards like GoodRx to find the lowest cost at different pharmacies.
Timolol Maleate
$50–$150/month
While a generic version of Timolol Maleate eye drops is available, the brand name 'Timolol Maleate' (often referring to specific formulations or strengths) might be more expensive. Patients can often find significant savings by using discount cards or manufacturer coupons, especially if a specific brand formulation is prescribed.
Compare prices for Paroxetine and Timolol Maleate
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.