Phenelzine Sulfate and Sertraline Hydrochloride must not be used together. This combination is classified as CONTRAINDICATED.
Concomitant use of sertraline and phenelzine is absolutely contraindicated due to a severe, potentially life-threatening risk of serotonin syndrome. This syndrome can manifest with mental status changes, autonomic instability, and neuromuscular abnormalities.
Mechanism: Sertraline increases serotonin levels by inhibiting its reuptake, while phenelzine, an MAOI, prevents serotonin breakdown. The combined effect leads to excessive accumulation of serotonin in the central nervous system.
Phenelzine Sulfate vs. Sertraline Hydrochloride
Compare Phenelzine Sulfate and Sertraline Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Phenelzine Sulfate
phenelzine sulfate
MAOIs (Monoamine Oxidase Inhibitors)
RxDrug B
Sertraline Hydrochloride
Sertraline hydrochloride
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxQuick Comparison
| Category | Phenelzine Sulfate | Sertraline Hydrochloride |
|---|---|---|
| Drug Class | MAOIs (Monoamine Oxidase Inhibitors) | SSRIs (Selective Serotonin Reuptake Inhibitors) |
| Rx Status | Rx | Rx |
| Generic Available | Yes | No |
| Typical Cost | $30-$80/month | $10–$50/month |
Phenelzine Sulfate Overview
PHENELZINE SULFATE (brand name: phenelzine sulfate) is a MAOIs. INDICATIONS AND USAGE Phenelzine sulfate has been found to be effective in depressed patients clinically characterized as "atypical," "nonendogenous," or "neurotic." These patients often have mixed anxiety and depression and phobic or hypochondriacal features. There is less conclusive evidence of…
Full Phenelzine Sulfate guide →Sertraline Hydrochloride Overview
Sertraline hydrochloride is an antidepressant medication belonging to a group called selective serotonin reuptake inhibitors (SSRIs). It helps improve mood and reduce symptoms by affecting a natural substance in the brain called serotonin. This medication is used to treat various conditions like depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxie...
Full Sertraline Hydrochloride guide →How Each Drug Works
Sertraline Hydrochloride
Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT).
Approved Uses (Indications)
Phenelzine Sulfate
INDICATIONS AND USAGE Phenelzine sulfate has been found to be effective in depressed patients clinically characterized as "atypical," "nonendogenous," or "neurotic." These patients often have mixed anxiety and depression and phobic or hypochondriacal features. There is less conclusive evidence of its usefulness with severely depressed patients with endogenous features. Phenelzine sulfate should rarely be the first antidepressant drug used. Rather, it is more suitable for use with patients who have failed to respond to the drugs more commonly used for these conditions.
Sertraline Hydrochloride
Sertraline hydrochloride oral solution is indicated for the treatment of the following [See Clinical Studies ] :
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Posttraumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD) Sertraline hydrochloride oral solution is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of :
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Posttraumatic stress disorde…
Side Effects
Phenelzine Sulfate
Sertraline Hydrochloride
Cost Comparison
Phenelzine Sulfate
$30-$80/month
Generic available
Generic phenelzine is available and generally more affordable than the brand-name Nardil. Prices can vary based on pharmacy, dosage, and insurance coverage. Manufacturer coupons or patient assistance programs may be available for eligible individuals.
Sertraline Hydrochloride
$10–$50/month
Sertraline is widely available as an affordable generic. Patients can often find significant savings using discount cards or pharmacy loyalty programs.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.