Combining Piroxicam and Rivaroxaban is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam with rivaroxaban significantly increases your risk of bleeding, including serious internal bleeding. You should avoid taking these medications together unless specifically directed by your doctor.
Mechanism: Piroxicam, an NSAID, inhibits prostaglandin synthesis, which reduces platelet aggregation and impairs the gastroprotective lining of the stomach. Rivaroxaban is a direct oral anticoagulant that inhibits Factor Xa, preventing clot formation. The concurrent use of these drugs leads to an additive antiplatelet and anticoagulant effect, and increased gastrointestinal mucosal damage, synergistically elevating bleeding risk.
Piroxicam vs. Rivaroxaban
Compare Piroxicam and Rivaroxaban: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Rivaroxaban
rivaroxaban
Anticoagulants
RxQuick Comparison
| Category | Piroxicam | Rivaroxaban |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$30/month | $400–$600/month |
Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →Rivaroxaban Overview
RIVAROXABAN (brand name: rivaroxaban) is a Anticoagulants. 1 INDICATIONS & USAGE Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) ( 1.7 ) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients…
Full Rivaroxaban guide →How Each Drug Works
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Rivaroxaban
Rivaroxaban is a selective inhibitor of FXa. It does not require a cofactor (such as Anti-thrombin III) for activity. Rivaroxaban inhibits free FXa and prothrombinase activity. Rivaroxaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, rivaroxaban decreases thrombin generation.
Approved Uses (Indications)
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Rivaroxaban
Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients after recent lower extremity revascularization due to symptomatic PAD 1.7 Reduction of Risk of Major Cardiovascular Events in Patients with Coronary Artery Disease (CAD) Rivaroxaban tablets, in combination with aspirin, are indicated to reduce the risk of major cardiovascular events (cardiova…
Side Effects
Piroxicam
Rivaroxaban
Cost Comparison
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
Rivaroxaban
$400–$600/month
As a brand-only medication, Rivaroxaban can be expensive. Check the manufacturer's website for patient assistance programs or coupons, and compare prices at different pharmacies using discount cards.
Compare prices for Piroxicam and Rivaroxaban
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.