Tapentadol Hydrochloride and Temazepam must not be used together. This combination is classified as CONTRAINDICATED.
The concurrent use of tapentadol and temazepam significantly increases the risk of severe respiratory depression, profound sedation, hypotension, coma, and death. Patients may experience decreased level of consciousness, slowed or shallow breathing, and psychomotor impairment.
Mechanism: Tapentadol, an opioid analgesic, acts as a mu-opioid receptor agonist and norepinephrine reuptake inhibitor, producing central nervous system (CNS) depression. Temazepam, a benzodiazepine, enhances the effect of gamma-aminobutyric acid (GABA) at the GABA-A receptor, also leading to profound CNS depression. The co-administration results in an additive and synergistic depressant effect on the CNS.
Tapentadol Hydrochloride vs. Temazepam
Compare Tapentadol Hydrochloride and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Tapentadol Hydrochloride
Tapentadol Hydrochloride
Opioid Analgesics
RxDrug B
Temazepam
temazepam
Benzodiazepines
RxQuick Comparison
| Category | Tapentadol Hydrochloride | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $300–$800/month | $20–$70/month |
Tapentadol Hydrochloride Overview
TAPENTADOL HYDROCHLORIDE (brand name: Tapentadol Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can…
Full Tapentadol Hydrochloride guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →How Each Drug Works
Tapentadol Hydrochloride
Tapentadol is a centrally-acting synthetic analgesic. The exact mechanism of action is unknown. Although the clinical relevance is unclear, preclinical studies have shown that tapentadol is a mu-opioid receptor (MOR) agonist and a norepinephrine reuptake inhibitor (NRI). Analgesia in animal models is derived from both of these properties.
Approved Uses (Indications)
Tapentadol Hydrochloride
Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dose or duration [see Warnings and Precautions ], and persist over the course of therapy, reserve opioid analgesics, including tapentadol tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide su…
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Tapentadol Hydrochloride
Temazepam
Cost Comparison
Tapentadol Hydrochloride
$300–$800/month
Since Tapentadol Hydrochloride is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to significantly reduce costs. Discount cards like GoodRx can also offer some savings.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.