Omeprazole Cost & Price Guide
Also sold as: Prilosec, Zegerid, Yosprala, Talicia +4 more
Omeprazole is widely available as an inexpensive generic. Using discount cards or purchasing store brand OTC versions can significantly reduce costs.
Per month, without insurance
Generic versions may cost significantly less
Discount coupons may reduce out-of-pocket costs
Cost Overview
Omeprazole is widely available as an inexpensive generic. Using discount cards or purchasing store brand OTC versions can significantly reduce costs.
Generic vs. Brand-Name Price
| Version | Typical Monthly Cost | Notes |
|---|---|---|
omeprazole (generic)Best Value | $4–$25/month | Same active ingredient as brand; FDA-approved bioequivalent |
| Prilosec(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Zegerid(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Yosprala(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
Generic Manufacturers
The following companies manufacture FDA-approved generic versions of Omeprazole. Prices may vary between manufacturers and pharmacies.
Available Forms & Strengths
Omeprazole is available in the following dosage forms. Prices may vary by form and strength.
Ways to Save on Omeprazole
Ask for the Generic
Generic omeprazole contains the same active ingredient and is FDA-approved as bioequivalent to the brand. Ask your pharmacist to dispense the generic to save significantly.
Prescription Discount Cards
Free discount programs like GoodRx, RxSaver, and NeedyMeds can reduce the cost of omeprazole at most pharmacies. Compare prices before filling.
90-Day Supply
Ordering a 90-day supply through a mail-order pharmacy often costs less per dose than monthly fills. Check with your insurance plan or pharmacy benefit manager.
Patient Assistance Programs
If you're uninsured or underinsured, the manufacturer may offer a patient assistance program (PAP) that provides omeprazole at low or no cost. Visit NeedyMeds.org or the manufacturer's website.
Insurance Coverage
Most insurance plans, including Medicare Part D and Medicaid, cover omeprazole (particularly the generic version). Coverage and copay amounts vary by plan tier and formulary. Contact your insurance provider or check your plan's drug formulary to confirm coverage.
Find the Best Price
Coupon & Price Comparison
Patient Assistance Programs (PAP)
If you're uninsured, underinsured, or cannot afford omeprazole, these programs may provide it at low or no cost.
Frequently Asked Questions About Omeprazole Cost
When is the best time to take omeprazole?
Omeprazole works best when taken 30–60 minutes before your first meal of the day. This allows the drug to be activated and block proton pumps before they are stimulated by eating.
How long can I take omeprazole?
OTC omeprazole is intended for 14-day courses, repeated no more than 3 times per year. Long-term use should be under medical supervision due to risks of B12 deficiency, bone loss, and magnesium deficiency.
Is omeprazole safe to take every day?
Short-term daily use is generally safe. Long-term daily use (months to years) carries risks including hypomagnesemia, bone fractures, and vitamin B12 deficiency. Discuss with your doctor if you need it for more than 8 weeks.
More Omeprazole Information
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.