Antiarrhythmics
Antiarrhythmic drugs are used to treat abnormal heart rhythms (arrhythmias) by modifying the electrical conduction properties of the heart. Amiodarone is a class III antiarrhythmic with a complex pharmacokinetic profile and extensive drug interaction potential.
Mechanism of Action
Antiarrhythmics work by changing the electrical signals in your heart. They do this by affecting how certain tiny channels in heart cells open and close, which controls the flow of charged particles like sodium, potassium, and calcium. By adjusting these electrical signals, these medicines can help stabilize the heart's rhythm and prevent it from beating too fast, too slow, or irregularly. This helps to restore a normal heart beat.
Clinical Uses
This class of drugs is primarily used to treat irregular heartbeats, also known as arrhythmias. They are prescribed for conditions like atrial fibrillation (a common type of irregular heartbeat), atrial flutter, and ventricular tachycardia, which can be life-threatening. These medications help to control the heart rate or restore a normal rhythm, improving symptoms and preventing serious complications for patients with these heart conditions.
Side Effects & Safety
Common side effects can include dizziness, nausea, fatigue, and blurred vision. More serious side effects to watch for include new or worsening arrhythmias, liver problems, lung damage, or thyroid issues, especially with certain medications like amiodarone. Some antiarrhythmics carry a Black Box Warning because they can increase the risk of death in certain patients, particularly those with existing heart problems, so careful monitoring is essential.
Antiarrhythmics Medications (12)
AMIODARONE HYDROCHLORIDE
Brand: Amiodarone Hydrochloride
AMIODARONE HYDROCHLORIDE (brand name: Amiodarone Hydrochloride) is a Antiarrhythmics. 1 INDICATIONS AND USAGE Amiodarone Hydrochloride Injection, USP is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone Hydrochloride…
$30-$80/month/month
DISOPYRAMIDE PHOSPHATE
Brand: Norpace CR, Norpace
DISOPYRAMIDE PHOSPHATE (brand name: Norpace CR) is a Antiarrhythmics. INDICATIONS AND USAGE Norpace and Norpace CR are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening. Because of the proarrhythmic effects of Norpace and Norpace CR, their use with…
$200–$500/month/month
DOFETILIDE
Brand: DOFETILIDE
DOFETILIDE (brand name: DOFETILIDE) is a Antiarrhythmics. INDICATIONS & USAGE Maintenance of Normal Sinus Rhythm (Delay in AF/AFl Recurrence) Dofetilide capsules are indicated for the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of…
$2,000–$4,000/month/month
DRONEDARONE
Brand: Multaq
DRONEDARONE (brand name: Multaq) is a Antiarrhythmics. 1 INDICATIONS AND USAGE MULTAQ ® is indicated to reduce the risk of hospitalization for atrial fibrillation in patients in sinus rhythm with a history of paroxysmal or persistent atrial fibrillation (AF) [see Clinical Studies (14) ] . MULTAQ is an antiarrhythmic drug indicated to reduce the risk of…
$500–$1,000/month/month
FLECAINIDE ACETATE
Brand: Flecainide Acetate
FLECAINIDE ACETATE (brand name: Flecainide Acetate) is a Antiarrhythmics. INDICATIONS AND USAGE In patients without structural heart disease, flecainide acetate tablets, USP are indicated for the prevention of — paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other…
$200–$500/month/month
LIDOCAINE HYDROCHLORIDE
Brand: Accucaine
LIDOCAINE HYDROCHLORIDE (brand name: Accucaine) is a Antiarrhythmics. INDICATIONS AND USAGE Lidocaine Hydrochloride Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by…
$200–$600/month/month
MEXILETINE HYDROCHLORIDE
Brand: MEXILETINE HYDROCHLORIDE
MEXILETINE HYDROCHLORIDE (brand name: MEXILETINE HYDROCHLORIDE) is a Antiarrhythmics. INDICATIONS AND USAGE Mexiletine hydrochloride capsules, USP are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening. Because of the proarrhythmic effects of mexiletine, its use…
$300–$800/month/month
PROCAINAMIDE HYDROCHLORIDE
Brand: Procainamide Hydrochloride
PROCAINAMIDE HYDROCHLORIDE (brand name: Procainamide Hydrochloride) is a Antiarrhythmics. INDICATIONS AND USAGE Procainamide Hydrochloride Injection is indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgement of the physician, are life-threatening. Because of the proarrhythmic effects of procainamide, its use…
$200–$600/month/month
PROPAFENONE HYDROCHLORIDE
Brand: Propafenone Hydrochloride
PROPAFENONE HYDROCHLORIDE (brand name: Propafenone Hydrochloride) is a Antiarrhythmics. 1 INDICATIONS AND USAGE Propafenone Hydrochloride Tablets are indicated to: • prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. • prolong the time to recurrence of paroxysmal…
$150–$400/month/month
QUINIDINE GLUCONATE
Brand: Quinidine Gluconate
QUINIDINE GLUCONATE (brand name: Quinidine Gluconate) is a Antiarrhythmics. INDICATIONS AND USAGE Conversion of atrial fibrillation/flutter In patients with symptomatic atrial fibrillation/flutter whose symptoms are not adequately controlled by measures that reduce the rate of ventricular response, quinidine gluconate is indicated as a means of restoring normal sinus…
$300–$600/month/month
QUINIDINE SULFATE TABLET
Brand: QUINIDINE SULFATE
QUINIDINE SULFATE TABLET (brand name: QUINIDINE SULFATE) is a Antiarrhythmics. INDICATIONS AND USAGE Conversion of Atrial Fibrillation/Flutter In patients with symptomatic atrial fibrillation/flutter whose symptoms are not adequately controlled by measures that reduce the rate of ventricular response, quinidine sulfate is indicated as a means of restoring normal sinus rhythm.…
$150–$400/month/month
SOTALOL HYDROCHLORIDE
Brand: Sotalol Hydrochloride
SOTALOL HYDROCHLORIDE (brand name: Sotalol Hydrochloride) is a Antiarrhythmics. INDICATIONS AND USAGE Sotalol hydrochloride tablets, USP are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that in the judgment of the physician are life-threatening. Because of the proarrhythmic effects of sotalol hydrochloride…
$30–$150/month/month
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