Compare prices for all 26 NSAIDs medications. Find the cheapest generic options, coupon availability, and patient assistance programs. Includes typical monthly costs with and without insurance.

26
Drugs in Class
0
With Generic
26
Coupon Available
$4-$15/month
Lowest Starting Cost

Price Comparison Table(sorted cheapest first)

#1

Ibuprofen

good neighbor pharmacy ibuprofen

$4-$15/month
Budget-Friendly
Coupon6 manufacturers
#2

Meloxicam

meloxicam

$4–$20/month
Budget-Friendly
Coupon6 manufacturers
#3

Naproxen

Naproxen

$4–$25/month
Budget-Friendly
Coupon6 manufacturers
#4

Acetaminophen, aspirin, caffeine

Headache Relief

$5–$20/month
Budget-Friendly
Coupon
#5

Acetaminophen, aspirin, caffeine tablet

Extra Strength Headache, Caseys 4good

$5–$20/month
Budget-Friendly
Coupon
#6

Aspirin

Aspirin Regular Strength

$5–$20/month
Budget-Friendly
Coupon
#7

Aspirin 81 mg

Aspirin Enteric Coated

$5–$20/month
Budget-Friendly
Coupon
#8

Alka-seltzer original flavor

Alka-Seltzer Original Flavor

$10–$30/month
Budget-Friendly
Coupon
#9

Diclofenac sodium

Diclofenac Sodium

$10-$30/month
Budget-Friendly
Coupon6 manufacturers
#10

Diphenhydramine citrate, ibuprofen

good sense ibuprofen pm

$10–$30/month
Budget-Friendly
Coupon
#11

Ibuprofen tablet, film-coated

Ibuprofen, Caseys 4good

$10–$30/month
Budget-Friendly
Coupon
#12

Ibuprofen, phenylephrine hcl

Equaline congestion relief

$10–$30/month
Budget-Friendly
Coupon
#13

Ketorolac tromethamine

Ketorolac Tromethamine

$10–$50/month
Budget-Friendly
Coupon6 manufacturers
#14

Piroxicam

Piroxicam

$10–$30/month
Budget-Friendly
Coupon5 manufacturers
#15

Acetaminophen, ibuprofen

Dual Action Pain Relief

$15–$40/month
Budget-Friendly
Coupon
#16

Etodolac

Etodolac

$15-$60/month
Budget-Friendly
Coupon6 manufacturers
#17

Ibuprofen, acetaminophen tablet, film coated

Advil Dual Action with Acetaminophen, Travel BASIX, Advil Dual Action with Acetaminophen

$15–$40/month
Budget-Friendly
Coupon
#18

Nabumetone

Nabumetone

$15–$50/month
Budget-Friendly
Coupon5 manufacturers
#19

Naproxen sodium 220mg

Naproxen Sodium 220mg

$15–$40/month
Budget-Friendly
Coupon
#20

Sulindac

SULINDAC

$15-$40/month
Budget-Friendly
Coupon6 manufacturers
#21

Diclofenac sodium topical gel, 1%

DICLOFENAC SODIUM

$20–$60/month
Moderate Cost
Coupon6 manufacturers
#22

Ibuprofen tablets

Ibuprofen, Caseys 4good

$20–$50/month
Moderate Cost
Coupon
#23

Naproxen sodium

All Day Back and Muscle Pain Relief

$20–$60/month
Moderate Cost
Coupon
#24

Indomethacin

Indomethacin

$30–$80/month
Moderate Cost
Coupon
#25

Celecoxib

celecoxib

$150–$400/month
Higher Cost
Coupon
#26

Diclofenac sodium, capsaicin

Lextol

$200–$500/month
Higher Cost
Coupon

Cost Notes by Drug

Ibuprofen

Ibuprofen is widely available as an inexpensive generic, even without insurance. Discount cards can further reduce the cost at many pharmacies.

Meloxicam

Meloxicam is available as an inexpensive generic. Patients can significantly reduce costs using discount cards or by checking prices at different pharmacies.

Naproxen

Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.

Acetaminophen, aspirin, caffeine

As an over-the-counter combination, this medication is generally inexpensive. Look for store brands or use coupons from retailers to save money.

Acetaminophen, aspirin, caffeine tablet

This combination drug is available over-the-counter and is very inexpensive. Look for store brands or use discount coupons to find the lowest price.

Aspirin

Aspirin is available over-the-counter at a very low cost, often less than $5 for a large supply. Discount cards can sometimes offer minor savings on the prescription version, but it's generally more cost-effective to buy OTC.

Aspirin 81 mg

Despite being a brand, Aspirin 81 mg is very inexpensive. Look for store brand or generic aspirin for even lower prices, and discount cards can often reduce the cost further.

Alka-seltzer original flavor

Alka-Seltzer Original Flavor is an over-the-counter product, but if prescribed, discount cards can often help reduce the cost. Compare prices at different pharmacies as they can vary.

Diclofenac sodium

Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.

Diphenhydramine citrate, ibuprofen

Since this is a combination of two common over-the-counter medications, purchasing generic diphenhydramine and ibuprofen separately may offer additional savings. Discount cards can also help reduce the cost.

Ibuprofen tablet, film-coated

While Ibuprofen is available over-the-counter for lower doses, the prescription strength may be covered by insurance or significantly reduced with discount cards like GoodRx.

Ibuprofen, phenylephrine hcl

As this is a combination of two common, inexpensive ingredients, even without insurance, the cost is typically low. Look for store brands or generic versions of similar over-the-counter products for the best price.

Ketorolac tromethamine

As a widely available generic, Ketorolac Tromethamine is typically inexpensive. Using discount cards like GoodRx can often reduce the cost further to just a few dollars per month.

Piroxicam

Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.

Acetaminophen, ibuprofen

Although this specific combination is brand-only, acetaminophen and ibuprofen are widely available as inexpensive generics. Discount cards or coupons can often help reduce the cost of the brand-name product.

Etodolac

Since Etodolac is available as a generic, using discount cards like GoodRx can significantly reduce the cash price. Always compare prices at different pharmacies.

Ibuprofen, acetaminophen tablet, film coated

As a brand-name, non-generic drug, prices can vary. Look for manufacturer coupons or use discount cards like GoodRx to help reduce the cost.

Nabumetone

Nabumetone is available as a generic, which significantly lowers its cost. Using discount cards like GoodRx can further reduce the price to as little as $15-20 per month.

Naproxen sodium 220mg

While the 220mg strength might be marketed as a brand, naproxen sodium is widely available as a low-cost generic. Using discount cards or checking prices at different pharmacies can significantly reduce your out-of-pocket cost.

Sulindac

As a generic medication, Sulindac is relatively inexpensive. Patients can often find significant savings by using discount cards or checking prices at different pharmacies.

Diclofenac sodium topical gel, 1%

Diclofenac Sodium Topical Gel is available as a generic, which is significantly cheaper than brand-name options. Using discount coupons from services like GoodRx can further reduce the out-of-pocket cost.

Ibuprofen tablets

While Ibuprofen is widely available as a low-cost generic, this specific brand-name version may be more expensive. Patients can often find significant savings by using discount cards or asking their pharmacist about generic alternatives.

Naproxen sodium

While a generic prescription is not available, discount cards can often significantly reduce the cost of brand-name Naproxen Sodium. Check for manufacturer coupons as well.

Indomethacin

While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.

Celecoxib

Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.

Diclofenac sodium, capsaicin

Since Lextol is a brand-only medication, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards like GoodRx may also offer some savings.

How to Save on NSAIDs Medications

Choose a Generic

0 of 26 NSAIDs drugs have generic versions available, which can cost 80–90% less than brand-name versions.

Use a Discount Card

GoodRx, RxSaver, and Blink Health can reduce out-of-pocket costs at most pharmacies, even if you have insurance.

Ask About 90-Day Supplies

Mail-order pharmacies often charge less per dose for 90-day fills compared to monthly fills at retail pharmacies.

Patient Assistance Programs

If you're uninsured or underinsured, NeedyMeds and RxAssist can connect you with manufacturer PAPs that may provide medications at no cost.

More NSAIDs Resources

Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.