Dulaglutide Drug Interactions
Also known as: Trulicity
Trulicity (dulaglutide) is a medication in a class called GLP-1 receptor agonists. It is used alongside diet and exercise to help adults and children aged 10 and older with type 2 diabetes manage their blood sugar levels. Additionally, for adults with type 2 diabetes who have heart disease or risk factors, Trulicity can help lower their risk of serious heart problems like heart attack or stroke.Dulaglutide has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
0
Contraindicated
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Major
1
Moderate
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Minor
When metformin and dulaglutide are used together, there is an increased risk of hypoglycemia due to their additive glucose-lowering effects. Patients may also experience increased gastrointestinal side effects such as nausea, vomiting, and diarrhea.
Mechanism
Both metformin and dulaglutide contribute to glucose lowering through different mechanisms (e.g., reduced hepatic glucose production, improved insulin sensitivity for metformin; increased insulin secretion, slowed gastric emptying for dulaglutide). Their combined effects can lead to an additive reduction in blood glucose.
Clinical Management
Patients should be monitored closely for signs and symptoms of hypoglycemia, especially when initiating or titrating either medication. Dose adjustments of one or both medications, particularly metformin, may be necessary to maintain glycemic control and minimize adverse effects. Advise patients on managing hypoglycemic episodes.
For complete prescribing information:
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