FUROSEMIDE Drug Interactions
Also known as: Furosemide
FUROSEMIDE (brand name: Furosemide) is a Loop Diuretics. INDICATIONS AND USAGE Edema Furosemide tablets are indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Furosemide is particularly useful when an agent with…FUROSEMIDE has 2 documented drug interactions in our database, including 0 contraindicated, 2 major, 0 moderate, and 0 minor interactions.
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Contraindicated
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Moderate
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Minor
Concomitant use of furosemide with lithium can significantly increase serum lithium levels, leading to an elevated risk of lithium toxicity. Patients may experience symptoms such as tremor, confusion, ataxia, and in severe cases, seizures or coma.
Mechanism
Furosemide, a loop diuretic, can cause sodium and water depletion. The kidneys compensate by increasing proximal tubular reabsorption of sodium and, consequently, lithium. This reduced renal clearance of lithium leads to its accumulation.
Clinical Management
Avoid concurrent use if possible. If co-administration is necessary, closely monitor serum lithium levels, especially during initiation or dose changes of furosemide, and adjust lithium dosage as needed. Monitor for signs and symptoms of lithium toxicity and maintain adequate hydration.
Furosemide, a loop diuretic, can cause hypokalemia and hypomagnesemia. These electrolyte imbalances significantly increase the risk of digoxin toxicity, potentially leading to severe cardiac arrhythmias and other adverse effects, even at therapeutic digoxin levels.
Mechanism
Furosemide-induced hypokalemia and hypomagnesemia enhance digoxin's binding to the Na+/K+-ATPase pump. This increased binding exacerbates the inhibitory effect of digoxin, leading to heightened intracellular calcium and subsequent toxicity.
Clinical Management
Closely monitor serum potassium, magnesium, and digoxin levels when co-administering furosemide and digoxin. Supplement potassium and/or magnesium as needed to maintain levels within the normal range to prevent digoxin toxicity. Adjust digoxin dose if necessary.
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