HYDROCODONE BITARTRATE Drug Interactions
Also known as: Zohydro ER
Hydrocodone extended-release is a strong opioid pain medicine used to manage severe and long-lasting pain that requires around-the-clock treatment. It is prescribed when other pain medicines have not worked or cannot be tolerated. This medication helps reduce pain by changing how your brain and nervous system respond to pain.HYDROCODONE BITARTRATE has 2 documented drug interactions in our database, including 0 contraindicated, 2 major, 0 moderate, and 0 minor interactions.
0
Contraindicated
2
Major
0
Moderate
0
Minor
Concomitant use of hydrocodone (an opioid) and lorazepam (a benzodiazepine) can lead to profound sedation, severe respiratory depression, coma, and death. This combination significantly increases the risk of life-threatening central nervous system depression.
Mechanism
Both hydrocodone and lorazepam cause central nervous system (CNS) depression. Hydrocodone acts on opioid receptors, while lorazepam enhances GABAergic activity. Their combined effects are additive, leading to synergistic CNS and respiratory depression.
Clinical Management
Avoid concomitant use if possible. If unavoidable, use the lowest effective doses for the shortest duration, closely monitor for respiratory depression and sedation, and educate patients/caregivers on warning signs. Consider naloxone availability.
Concomitant use of hydrocodone and alprazolam can lead to profound sedation, respiratory depression, coma, and death. This combination should generally be avoided due to the increased risk of life-threatening adverse effects.
Mechanism
Both hydrocodone (an opioid) and alprazolam (a benzodiazepine) are central nervous system depressants. Their co-administration results in an additive pharmacodynamic depressant effect on the CNS, particularly on the respiratory drive.
Clinical Management
Avoid concomitant use whenever possible. If co-prescription is unavoidable, limit dosages and duration to the minimum necessary, and monitor patients closely for signs of respiratory depression and sedation. Educate patients and caregivers on the risks and symptoms to watch for.
For complete prescribing information:
View full HYDROCODONE BITARTRATE monograph →Medical Disclaimer
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