metformin Drug Interactions
Also known as: Glucophage, Glumetza, Fortamet, Kazano, Jentadueto, Kombiglyze, Janumet, Invokamet, Xigduo, Synjardy, Segluromet, Trijardy, Zituvimet, Riomet, Actoplus Met
Metformin (brand name: Glucophage) is the first-line oral medication for type 2 diabetes. It works by reducing glucose production in the liver and improving insulin sensitivity in muscle and fat tissue.metformin has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 0 moderate, and 1 minor interactions.
0
Contraindicated
0
Major
0
Moderate
1
Minor
NSAIDs may slightly reduce metformin's renal clearance and increase the risk of lactic acidosis in patients with renal impairment.
Mechanism
NSAIDs reduce renal blood flow and GFR, potentially reducing metformin elimination and increasing plasma levels.
Clinical Management
Use with caution in patients with renal impairment. Monitor renal function. Use acetaminophen as an alternative when possible.
For complete prescribing information:
View full metformin monograph →Medical Disclaimer
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