Semaglutide Drug Interactions
Also known as: Ozempic, Rybelsus, Wegovy
Semaglutide (Ozempic, Wegovy, Rybelsus) is a GLP-1 receptor agonist approved for type 2 diabetes, weight management, and cardiovascular risk reduction. See the full semaglutide monograph for complete prescribing information.Semaglutide has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
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Contraindicated
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Major
1
Moderate
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Minor
Combining metformin and oral semaglutide can lead to an increased risk of hypoglycemia (low blood sugar) due to their additive glucose-lowering effects. Patients may experience symptoms such as dizziness, sweating, confusion, or tremor. While generally beneficial for blood sugar control, close monitoring is essential.
Mechanism
Both metformin and semaglutide work to lower blood glucose through different mechanisms. Metformin decreases hepatic glucose production and improves insulin sensitivity, while semaglutide, a GLP-1 receptor agonist, stimulates insulin secretion, suppresses glucagon secretion, and slows gastric emptying. Their combined actions can lead to a synergistic reduction in blood glucose levels.
Clinical Management
Monitor blood glucose levels more frequently, especially when initiating or titrating either medication. If hypoglycemia occurs, a dose reduction of one or both medications, particularly any concomitant insulin secretagogues (e.g., sulfonylureas) or insulin, may be necessary. Educate patients on recognizing and treating hypoglycemia.
For complete prescribing information:
View full Semaglutide monograph →Already managing multiple medications?
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