Levothyroxine sodium Cost & Price Guide
Also sold as: Synthroid, Levoxyl, Unithroid, Tirosint
Generic levothyroxine is one of the most affordable medications available. A 30-day supply of generic levothyroxine 100 mcg typically costs $10–$30 at most pharmacies without insurance. With a GoodRx coupon, prices can be as low as $5–$15. The brand-name Synthroid costs significantly more. Most insurance plans cover generic levothyroxine at the lowest tier copay. Note that because levothyroxine has a narrow therapeutic index, some physicians recommend staying on the same brand or manufacturer.
Per month, without insurance
Generic versions may cost significantly less
Discount coupons may reduce out-of-pocket costs
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Cost Overview
Generic levothyroxine is one of the most affordable medications available. A 30-day supply of generic levothyroxine 100 mcg typically costs $10–$30 at most pharmacies without insurance. With a GoodRx coupon, prices can be as low as $5–$15. The brand-name Synthroid costs significantly more. Most insurance plans cover generic levothyroxine at the lowest tier copay. Note that because levothyroxine has a narrow therapeutic index, some physicians recommend staying on the same brand or manufacturer.
Generic vs. Brand-Name Price
| Version | Typical Monthly Cost | Notes |
|---|---|---|
levothyroxine sodium (generic)Best Value | $10–$30/month | Same active ingredient as brand; FDA-approved bioequivalent |
| Synthroid(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Levoxyl(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Unithroid(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
Generic Manufacturers
The following companies manufacture FDA-approved generic versions of Levothyroxine sodium. Prices may vary between manufacturers and pharmacies.
Available Forms & Strengths
Levothyroxine sodium is available in the following dosage forms. Prices may vary by form and strength.
Ways to Save on Levothyroxine sodium
Ask for the Generic
Generic levothyroxine sodium contains the same active ingredient and is FDA-approved as bioequivalent to the brand. Ask your pharmacist to dispense the generic to save significantly.
Prescription Discount Cards
Free discount programs like GoodRx, RxSaver, and NeedyMeds can reduce the cost of levothyroxine sodium at most pharmacies. Compare prices before filling.
90-Day Supply
Ordering a 90-day supply through a mail-order pharmacy often costs less per dose than monthly fills. Check with your insurance plan or pharmacy benefit manager.
Patient Assistance Programs
If you're uninsured or underinsured, the manufacturer may offer a patient assistance program (PAP) that provides levothyroxine sodium at low or no cost. Visit NeedyMeds.org or the manufacturer's website.
Insurance Coverage
Most insurance plans, including Medicare Part D and Medicaid, cover levothyroxine sodium (particularly the generic version). Coverage and copay amounts vary by plan tier and formulary. Contact your insurance provider or check your plan's drug formulary to confirm coverage.
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Patient Assistance Programs (PAP)
If you're uninsured, underinsured, or cannot afford levothyroxine sodium, these programs may provide it at low or no cost.
Frequently Asked Questions About Levothyroxine sodium Cost
What is levothyroxine used for?
Levothyroxine is used as replacement therapy for hypothyroidism (underactive thyroid gland), including primary hypothyroidism caused by Hashimoto's thyroiditis, thyroid surgery, or radioiodine treatment. It is also used to suppress TSH (thyroid-stimulating hormone) in patients with thyroid cancer, and to treat or prevent goiter (enlarged thyroid gland).
When is the best time to take levothyroxine?
Levothyroxine should be taken on an empty stomach, 30–60 minutes before breakfast, with a full glass of water. Taking it with food, especially high-fiber foods, calcium, or iron supplements, significantly reduces absorption. Some patients take it at bedtime (at least 3–4 hours after the last meal) as an alternative, which may improve absorption in some people.
What is the difference between levothyroxine and Synthroid?
Synthroid is the brand name for levothyroxine sodium manufactured by AbbVie. Generic levothyroxine is bioequivalent to Synthroid and is available from multiple manufacturers. However, because levothyroxine has a narrow therapeutic index, some endocrinologists recommend staying on the same brand or manufacturer to avoid small variations in absorption. If switching between brands or generics, TSH levels should be rechecked 6–8 weeks after the change.
How long does it take for levothyroxine to work?
Levothyroxine has a half-life of about 7 days, so it takes 4–6 weeks to reach steady-state blood levels. Most patients begin to notice improvement in hypothyroid symptoms (fatigue, weight gain, cold intolerance) within 2–4 weeks, but full normalization of TSH levels and complete symptom resolution typically takes 6–8 weeks. TSH levels should be checked 6–8 weeks after starting or changing the dose.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.