Semaglutide Cost & Price Guide
Also sold as: Ozempic, Wegovy, Rybelsus
Semaglutide is available under three brand names with different pricing structures: **Ozempic (injectable, diabetes indication):** - List price: approximately $935–$968 per 4-week supply (all doses) - With Novo Nordisk savings card: as low as $25/month for eligible commercially insured patients - Medicare Part D: covered for type 2 diabetes; prior authorization typically required **Wegovy (injectable, weight management):** - List price: approximately $1,349/month - With Novo Nordisk savings card: as low as $25/month for eligible commercially insured patients - Medicare Part D: covered for weight management (Inflation Reduction Act, 2024) and for cardiovascular risk reduction (SELECT indication); ~$50–$100/month copay typical **Rybelsus (oral tablet):** - List price: approximately $935–$968/month (same as Ozempic) - With Novo Nordisk savings card: as low as $10/month for eligible commercially insured patients - Medicare Part D: covered for type 2 diabetes No FDA-approved generic semaglutide exists as of 2026. Compounded semaglutide is no longer permitted under the shortage exemption following the FDA's declaration that the shortage has been resolved (March 2025 for Ozempic/Wegovy; April 2025 for Rybelsus).
Per month, without insurance
Only brand-name versions currently available
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Cost Overview
Semaglutide is available under three brand names with different pricing structures:
Ozempic (injectable, diabetes indication):
- List price: approximately $935–$968 per 4-week supply (all doses)
- With Novo Nordisk savings card: as low as $25/month for eligible commercially insured patients
- Medicare Part D: covered for type 2 diabetes; prior authorization typically required
Wegovy (injectable, weight management):
- List price: approximately $1,349/month
- With Novo Nordisk savings card: as low as $25/month for eligible commercially insured patients
- Medicare Part D: covered for weight management (Inflation Reduction Act, 2024) and for cardiovascular risk reduction (SELECT indication); ~$50–$100/month copay typical
Rybelsus (oral tablet):
- List price: approximately $935–$968/month (same as Ozempic)
- With Novo Nordisk savings card: as low as $10/month for eligible commercially insured patients
- Medicare Part D: covered for type 2 diabetes
No FDA-approved generic semaglutide exists as of 2026. Compounded semaglutide is no longer permitted under the shortage exemption following the FDA's declaration that the shortage has been resolved (March 2025 for Ozempic/Wegovy; April 2025 for Rybelsus).
Generic vs. Brand-Name Price
| Version | Typical Monthly Cost | Notes |
|---|---|---|
| Ozempic(brand) | $935–$1,349/month | Check manufacturer patient assistance programs |
| Wegovy(brand) | $935–$1,349/month | Check manufacturer patient assistance programs |
| Rybelsus(brand) | $935–$1,349/month | Check manufacturer patient assistance programs |
Available Forms & Strengths
Semaglutide is available in the following dosage forms. Prices may vary by form and strength.
Ways to Save on Semaglutide
Prescription Discount Cards
Free discount programs like GoodRx, RxSaver, and NeedyMeds can reduce the cost of semaglutide at most pharmacies. Compare prices before filling.
90-Day Supply
Ordering a 90-day supply through a mail-order pharmacy often costs less per dose than monthly fills. Check with your insurance plan or pharmacy benefit manager.
Patient Assistance Programs
If you're uninsured or underinsured, the manufacturer may offer a patient assistance program (PAP) that provides semaglutide at low or no cost. Visit NeedyMeds.org or the manufacturer's website.
Insurance Coverage
Most insurance plans, including Medicare Part D and Medicaid, cover semaglutide . Coverage and copay amounts vary by plan tier and formulary. Contact your insurance provider or check your plan's drug formulary to confirm coverage.
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Patient Assistance Programs (PAP)
If you're uninsured, underinsured, or cannot afford semaglutide, these programs may provide it at low or no cost.
Frequently Asked Questions About Semaglutide Cost
What is semaglutide used for?
Semaglutide is used for three main purposes depending on the brand: (1) Ozempic — type 2 diabetes and cardiovascular risk reduction; (2) Wegovy — chronic weight management and cardiovascular risk reduction in adults with obesity; (3) Rybelsus — type 2 diabetes (oral tablet). All three contain the same active molecule at different doses.
What is the difference between Ozempic, Wegovy, and Rybelsus?
All three are semaglutide, but they differ in dose, form, and FDA indication. Ozempic (0.5–2 mg injectable, once weekly) is approved for type 2 diabetes. Wegovy (2.4 mg injectable, once weekly) is approved for weight loss and cardiovascular risk reduction — it uses a higher dose than Ozempic. Rybelsus (3–14 mg oral tablet, once daily) is the only oral GLP-1 agonist and is approved for type 2 diabetes.
How does semaglutide cause weight loss?
Semaglutide activates GLP-1 receptors in the brain's hypothalamus and brainstem, which reduces hunger signals and increases feelings of fullness. It also slows gastric emptying, so food stays in the stomach longer, further reducing appetite. At the Wegovy dose (2.4 mg), clinical trials show an average weight loss of 15% of body weight over 68 weeks.
How do you take Rybelsus (oral semaglutide)?
Rybelsus must be taken on an empty stomach with no more than 4 oz (120 mL) of plain water. Wait at least 30 minutes before eating, drinking anything other than water, or taking other oral medications. Taking Rybelsus with food or other beverages can reduce absorption by up to 50%. Start at 3 mg once daily for 30 days, then increase to 7 mg, then 14 mg if needed.
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