Opioid Analgesics Cost Comparison

Opioid Analgesics

Compare prices for all 25 Opioid Analgesics medications. Find the cheapest generic options, coupon availability, and patient assistance programs. Includes typical monthly costs with and without insurance.

25
Drugs in Class
1
With Generic
23
Coupon Available
$10
Lowest Starting Cost

Price Comparison Table(sorted cheapest first)

#1

Codeine sulfate

Codeine sulfate

$10–$50/month
Budget-Friendly
Coupon
#2

Methadone

Methadone Hydrochloride

$15–$60/month
Budget-Friendly
Coupon5 manufacturers
#3

Tramadol hydrochloride

TRAMADOL HYDROCHLORIDE

$15–$50/month
Budget-Friendly
Coupon
#4

Morphine sulfate

Morphine Sulfate

$20–$150/month
Moderate Cost
Coupon
#5

Methadone hydrochloride

Methadone Hydrochloride

$30–$150/month
Moderate Cost
Coupon
#6

Oxycodone hydrochloride oral solution

Oxycodone Hydrochloride Oral Solution

$30–$100/month
Moderate Cost
Coupon
#7

Buprenorphine

BUPRENORPHINE

$50–$300/month
Moderate Cost
Coupon
#8

Morphine tincture

Opium Tincture Deodorized

$50–$150/month
Moderate Cost
Coupon
#9

Oxycodone hydrochloride

Oxycodone Hydrochloride

$50–$300/month
Moderate Cost
Coupon
#10

Buprenorphine sublingual

Buprenorphine Sublingual

$100–$300/month
Higher Cost
Coupon
#11

Nalbuphine hydrochloride

Nalbuphine Hydrochloride

$100–$400/month
Higher Cost
Coupon
#12

Fentanyl

FENTANYL

$150–$600/month
Higher Cost
Coupon
#13

Fentanyl transdermal

FENTANYL TRANSDERMAL

$150–$400/month
Higher Cost
Coupon
#14

Hydrocodone bitartrate

Zohydro ER

$150-$400/month
Higher Cost
Generic Coupon1 manufacturer
#15

Buprenorphine hydrochloride

buprenorphine hydrochloride

$200–$600/month
Higher Cost
Coupon
#16

Buprenorphine sublingual c-iii

Buprenorphine Sublingual C-III

$200–$600/month
Higher Cost
Coupon
#17

Hydromorphone hydrochloride

Hydromorphone Hydrochloride

$200–$500/month
Higher Cost
#18

Morphine

Opium Tincture Deodorized

$200–$600/month
Higher Cost
Coupon
#19

Oxycodone

Oxycodone Hydrochloride

$200–$600/month
Higher Cost
Coupon
#20

Oxymorphone hydrochloride

Oxymorphone Hydrochloride

$200–$800/month
Higher Cost
Coupon
#21

Sufentanil

Dsuvia

$200–$500 per dose
Higher Cost
#22

Tramadol hcl er

Tramadol HCL ER

$200–$600/month
Higher Cost
Coupon
#23

Tapentadol hydrochloride

Tapentadol Hydrochloride

$300–$800/month
Higher Cost
Coupon
#24

Fentanyl citrate

Fentanyl Citrate

$500–$2,000+/month
Higher Cost
Coupon
#25

Nalbuphine hci

NALBUPHINE HCI

$500–$1,500/month
Higher Cost
Coupon

Cost Notes by Drug

Codeine sulfate

As a generic medication, Codeine Sulfate is relatively inexpensive. Using a discount card or coupon can often reduce the cash price further.

Methadone

Generic methadone is very affordable, especially with discount cards like GoodRx. Many pharmacies offer low-cost programs for this medication.

Tramadol hydrochloride

Tramadol Hydrochloride is available as a generic, making it generally affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $20 per month.

Morphine sulfate

Despite being a brand-only drug, Morphine Sulfate is often available at a lower cost than many other brand medications. Always check with discount cards and compare pharmacy prices to find the best deal.

Methadone hydrochloride

Even though a generic is not available, discount cards can often significantly reduce the out-of-pocket cost for methadone. Always compare prices at different pharmacies.

Oxycodone hydrochloride oral solution

While there are no generic manufacturers for this specific oral solution, discount cards like GoodRx can often help reduce the out-of-pocket cost significantly. Always compare prices at different pharmacies.

Buprenorphine

While Buprenorphine is available as a generic, prices can vary significantly depending on the specific formulation and dosage. Using discount cards like GoodRx can often help reduce the out-of-pocket cost.

Morphine tincture

As this is a brand-only medication, discount cards or manufacturer coupons may help reduce the out-of-pocket cost. Patients should inquire about patient assistance programs if costs remain a barrier.

Oxycodone hydrochloride

While a generic is not available, discount cards like GoodRx can often help reduce the cost. Patients should also inquire about patient assistance programs offered by manufacturers or non-profit organizations.

Buprenorphine sublingual

As this is a brand-only medication, look for manufacturer coupons or patient assistance programs. Discount cards like GoodRx can also help reduce the out-of-pocket cost.

Nalbuphine hydrochloride

Since Nalbuphine Hydrochloride is often administered in a clinical setting, out-of-pocket costs may be covered by your medical insurance. For outpatient prescriptions, discount cards or patient assistance programs may offer significant savings.

Fentanyl

As a brand-only medication, fentanyl can be expensive. Patients should check for manufacturer coupons or patient assistance programs, and compare prices at different pharmacies using discount cards.

Fentanyl transdermal

Although there is no generic, manufacturer coupons or patient assistance programs may significantly reduce the cost of Fentanyl Transdermal. Always compare prices at different pharmacies and consider discount cards.

Hydrocodone bitartrate

Generic versions of extended-release hydrocodone are not widely available under this specific formulation (Zohydro ER was a brand name for a pure hydrocodone ER product). Costs can vary significantly based on insurance coverage and pharmacy. Manufacturer coupons or patient assistance programs may be available.

Buprenorphine hydrochloride

Since buprenorphine hydrochloride is currently brand-only, consider manufacturer patient assistance programs. Discount cards may offer some savings, but the cost without insurance remains significant.

Buprenorphine sublingual c-iii

As there is no generic available, look for manufacturer coupons or patient assistance programs to significantly reduce the cost. Discount cards like GoodRx may also offer some savings.

Hydromorphone hydrochloride

As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.

Morphine

As there is no generic available, patients should look for manufacturer patient assistance programs or discount cards to help reduce the cost of Opium Tincture Deodorized.

Oxycodone

As a brand-name medication, costs can be high without insurance. Manufacturer coupons or patient assistance programs may offer significant savings.

Oxymorphone hydrochloride

Since a generic is not available, patients may find discounts using manufacturer coupons or patient assistance programs. Comparing prices at different pharmacies with discount cards can also help reduce costs.

Sufentanil

Dsuvia is a brand-only medication typically administered in a supervised medical setting, making direct patient purchase and coupon use uncommon. Cost is usually covered by insurance or the facility.

Tramadol hcl er

As a brand-only medication, costs can be high without insurance. Look for manufacturer coupons or patient assistance programs, and compare prices at different pharmacies using discount cards.

Tapentadol hydrochloride

Since Tapentadol Hydrochloride is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to significantly reduce costs. Discount cards like GoodRx can also offer some savings.

Fentanyl citrate

Since Fentanyl Citrate is a brand-name drug, look for manufacturer patient assistance programs or coupons to significantly reduce costs. Discount cards like GoodRx may also offer some savings.

Nalbuphine hci

As Nalbuphine HCl is a brand-only medication, costs can be high without insurance. Look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the price.

How to Save on Opioid Analgesics Medications

Choose a Generic

1 of 25 Opioid Analgesics drugs have generic versions available, which can cost 80–90% less than brand-name versions.

Use a Discount Card

GoodRx, RxSaver, and Blink Health can reduce out-of-pocket costs at most pharmacies, even if you have insurance.

Ask About 90-Day Supplies

Mail-order pharmacies often charge less per dose for 90-day fills compared to monthly fills at retail pharmacies.

Patient Assistance Programs

If you're uninsured or underinsured, NeedyMeds and RxAssist can connect you with manufacturer PAPs that may provide medications at no cost.

More Opioid Analgesics Resources

Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.