SERTRALINE HYDROCHLORIDE Drug Interactions
Also known as: Sertraline hydrochloride
Sertraline hydrochloride is an antidepressant medication belonging to a group called selective serotonin reuptake inhibitors (SSRIs). It helps improve mood and reduce symptoms by affecting a natural substance in the brain called serotonin. This medication is used to treat various conditions like depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder.SERTRALINE HYDROCHLORIDE has 2 documented drug interactions in our database, including 0 contraindicated, 2 major, 0 moderate, and 0 minor interactions.
0
Contraindicated
2
Major
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Moderate
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Minor
Co-administration of sertraline and fluoxetine, both potent serotonin reuptake inhibitors, significantly increases the risk of Serotonin Syndrome. Patients may experience symptoms such as mental status changes, autonomic instability, neuromuscular abnormalities, and gastrointestinal symptoms.
Mechanism
Both sertraline and fluoxetine increase serotonin levels in the central nervous system by inhibiting serotonin reuptake. Combining these agents leads to an additive effect, resulting in excessive serotonergic activity.
Clinical Management
Concomitant use of sertraline and fluoxetine is generally not recommended due to the high risk of Serotonin Syndrome. If co-administration is deemed necessary, monitor patients closely for signs and symptoms of Serotonin Syndrome, and consider dose reductions or alternative therapies.
Concomitant use of warfarin and sertraline can significantly increase the risk of bleeding, including serious or life-threatening hemorrhage. Sertraline may enhance the anticoagulant effect of warfarin, necessitating close monitoring.
Mechanism
Sertraline may inhibit the metabolism of warfarin (particularly S-warfarin via CYP2C9), increasing its plasma concentrations. Additionally, sertraline's serotonergic effects can impair platelet aggregation, contributing to an increased bleeding risk.
Clinical Management
Avoid co-administration if possible. If concomitant use is necessary, closely monitor INR and clinical signs of bleeding, especially during initiation or dose changes of sertraline. Adjust warfarin dose as needed to maintain target INR.
For complete prescribing information:
View full SERTRALINE HYDROCHLORIDE monograph →Medical Disclaimer
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